Treatment of Lymphangiomas With OK-432 (Picibanil) Sclerotherapy

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Treatment of lymphangiomas with OK-432 (Picibanil) sclerotherapy: a prospective multi-institutional trial.

OBJECTIVE To describe and to determine the robustness of our study evaluating the efficacy of OK-432 (Picibanil) as a therapeutic modality for lymphangiomas. DESIGN AND SETTING Prospective, randomized trial and parallel-case series at 13 US tertiary care referral centers. SUBJECTS Thirty patients diagnosed as having lymphangioma. Ages in 25 ranged from 6 months to 18 years. Twenty-nine had ...

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Sclerosing treatment of lymphangiomas with OK-432.

Over a period of seven years, 15 patients (aged from birth to 15 years; median 22 months) with lymphangioma were treated with OK-432; they received a mean of three injections each. Ten received OK-432 as first line treatment; five were treated after surgery (three had a residual lymphangioma after incomplete removal and two had a late recurrence). OK-432 proved to be effective for primitive as ...

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[Unsuccessful treatment with OK-432 picibanil for orbital lymphangioma].

INTRODUCTION Lymphangioma is a malformation of the lymphatic system. The classic approach is surgery. We report a case of orbital lymphangioma in a girl who was given OK-432 to avoid surgery and its complications. DISCUSSION OK-432 is a lyophilized mixture of group A Streptococcus pyogenes which produces a fibrosis limited to the lesion with a high cure rate. The main advantages are the easy ...

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Ok-432 (Picibanil) In the Treatment of Ranulas

appearance of the ‘tail sign’ is vital for distinguishing plunging ranulas. However, these images are insufficient to differentiate between cystic hygroma, second branchial cleft cyst, or dermoid cysts [4]. USG can be used preoperatively to determine the characteristics of pediatric ranulas, and are a radiation-free and a rather inexpensive modality [2]. Plunging ranula diagnosis is complicated...

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OK-432 sclerotherapy in head and neck lymphangiomas: long-term follow-up result.

INTRODUCTION Nonsurgical treatments, such as sclerotherapy have been attempted for head and neck lymphagiomas. Of the available sclerosing agents, picibanil has shown satisfactory short-term treatment results in many studies, but no study has presented long-term treatment results. Accordingly, in the present study, the authors retrospectively reviewed the long-term treatment results of picibani...

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ژورنال

عنوان ژورنال: Archives of Otolaryngology–Head & Neck Surgery

سال: 2002

ISSN: 0886-4470

DOI: 10.1001/archotol.128.10.1137